Plant Transcription Factor Database
Previous version: v3.0
Solanum tuberosum
M-type_MADS Family
Species TF ID Description
PGSC0003DMP400000025M-type_MADS family protein
PGSC0003DMP400000151M-type_MADS family protein
PGSC0003DMP400002114M-type_MADS family protein
PGSC0003DMP400007950M-type_MADS family protein
PGSC0003DMP400009091M-type_MADS family protein
PGSC0003DMP400009108M-type_MADS family protein
PGSC0003DMP400010597M-type_MADS family protein
PGSC0003DMP400011154M-type_MADS family protein
PGSC0003DMP400013576M-type_MADS family protein
PGSC0003DMP400016526M-type_MADS family protein
PGSC0003DMP400016559M-type_MADS family protein
PGSC0003DMP400020035M-type_MADS family protein
PGSC0003DMP400020055M-type_MADS family protein
PGSC0003DMP400023055M-type_MADS family protein
PGSC0003DMP400029412M-type_MADS family protein
PGSC0003DMP400029415M-type_MADS family protein
PGSC0003DMP400031036M-type_MADS family protein
PGSC0003DMP400032449M-type_MADS family protein
PGSC0003DMP400032740M-type_MADS family protein
PGSC0003DMP400033688M-type_MADS family protein
PGSC0003DMP400033689M-type_MADS family protein
PGSC0003DMP400033931M-type_MADS family protein
PGSC0003DMP400034313M-type_MADS family protein
PGSC0003DMP400038946M-type_MADS family protein
PGSC0003DMP400038948M-type_MADS family protein
PGSC0003DMP400038950M-type_MADS family protein
PGSC0003DMP400038951M-type_MADS family protein
PGSC0003DMP400041060M-type_MADS family protein
PGSC0003DMP400041539M-type_MADS family protein
PGSC0003DMP400041540M-type_MADS family protein
PGSC0003DMP400041953M-type_MADS family protein
PGSC0003DMP400042972M-type_MADS family protein
PGSC0003DMP400043181M-type_MADS family protein
PGSC0003DMP400043212M-type_MADS family protein
PGSC0003DMP400043869M-type_MADS family protein
PGSC0003DMP400045466M-type_MADS family protein
PGSC0003DMP400045468M-type_MADS family protein
PGSC0003DMP400045469M-type_MADS family protein
PGSC0003DMP400045470M-type_MADS family protein
PGSC0003DMP400046189M-type_MADS family protein
PGSC0003DMP400046670M-type_MADS family protein
PGSC0003DMP400048491M-type_MADS family protein
PGSC0003DMP400049894M-type_MADS family protein
PGSC0003DMP400050751M-type_MADS family protein
PGSC0003DMP400052339M-type_MADS family protein
PGSC0003DMP400055871M-type_MADS family protein
PGSC0003DMP400056712M-type_MADS family protein
PGSC0003DMP400056931M-type_MADS family protein
PGSC0003DMP400057244M-type_MADS family protein
PGSC0003DMP400057325M-type_MADS family protein
PGSC0003DMP400057351M-type_MADS family protein
PGSC0003DMP400057567M-type_MADS family protein
PGSC0003DMP400057580M-type_MADS family protein
PGSC0003DMP400057605M-type_MADS family protein
PGSC0003DMP400058110M-type_MADS family protein
PGSC0003DMP400058229M-type_MADS family protein
PGSC0003DMP400058264M-type_MADS family protein
PGSC0003DMP400058294M-type_MADS family protein
PGSC0003DMP400058338M-type_MADS family protein
PGSC0003DMP400058518M-type_MADS family protein
PGSC0003DMP400058631M-type_MADS family protein
PGSC0003DMP400059446M-type_MADS family protein
PGSC0003DMP400059476M-type_MADS family protein
PGSC0003DMP400059843M-type_MADS family protein
PGSC0003DMP400060286M-type_MADS family protein
PGSC0003DMP400060311M-type_MADS family protein
PGSC0003DMP400060329M-type_MADS family protein
PGSC0003DMP400060643M-type_MADS family protein
PGSC0003DMP400060721M-type_MADS family protein
PGSC0003DMP400060834M-type_MADS family protein
PGSC0003DMP400061386M-type_MADS family protein
PGSC0003DMP400061462M-type_MADS family protein
PGSC0003DMP400061641M-type_MADS family protein
PGSC0003DMP400061699M-type_MADS family protein
PGSC0003DMP400061778M-type_MADS family protein
PGSC0003DMP400061939M-type_MADS family protein
PGSC0003DMP400062231M-type_MADS family protein
PGSC0003DMP400062261M-type_MADS family protein
PGSC0003DMP400062389M-type_MADS family protein
PGSC0003DMP400062729M-type_MADS family protein
PGSC0003DMP400062847M-type_MADS family protein
PGSC0003DMP400062952M-type_MADS family protein
PGSC0003DMP400063103M-type_MADS family protein
PGSC0003DMP400063139M-type_MADS family protein
PGSC0003DMP400063325M-type_MADS family protein
PGSC0003DMP400063515M-type_MADS family protein
PGSC0003DMP400064060M-type_MADS family protein
PGSC0003DMP400064104M-type_MADS family protein
PGSC0003DMP400064546M-type_MADS family protein
PGSC0003DMP400064792M-type_MADS family protein
PGSC0003DMP400064994M-type_MADS family protein
PGSC0003DMP400065322M-type_MADS family protein
PGSC0003DMP400065699M-type_MADS family protein
PGSC0003DMP400065718M-type_MADS family protein
PGSC0003DMP400065737M-type_MADS family protein
PGSC0003DMP400066082M-type_MADS family protein
PGSC0003DMP400066335M-type_MADS family protein
PGSC0003DMP400066389M-type_MADS family protein
PGSC0003DMP400066491M-type_MADS family protein
PGSC0003DMP400066561M-type_MADS family protein
PGSC0003DMP400066617M-type_MADS family protein
PGSC0003DMP400066672M-type_MADS family protein
PGSC0003DMP400066680M-type_MADS family protein
PGSC0003DMP400066737M-type_MADS family protein
PGSC0003DMP400066766M-type_MADS family protein
PGSC0003DMP400066865M-type_MADS family protein
PGSC0003DMP400067343M-type_MADS family protein
PGSC0003DMP400067753M-type_MADS family protein
PGSC0003DMP400067946M-type_MADS family protein
PGSC0003DMP400068756M-type_MADS family protein
PGSC0003DMP400068810M-type_MADS family protein
PGSC0003DMP400068840M-type_MADS family protein
PGSC0003DMP400069166M-type_MADS family protein
PGSC0003DMP400069389M-type_MADS family protein
M-type_MADS (M-type MADS) Family Introduction

The best studied plant MADS-box transcription factors are those involved in floral organ identity determination. Analysis of homeotic floral mutants resulted in the formulation of a genetic model, named the ABC model, that explains how the combined functions of three classes of genes (A, B, and C) determine the identity of the four flower organs (reviewed by Coen and Meyerowitz, 1991). Arabidopsis has two A-class genes (AP1 and AP2 [Bowman et al., 1989]), two B-class genes (PI and AP3), and a single C-class gene (AG), of which only AP2 is not a MADS-box gene. Recently, it was shown that the Arabidopsis B- and C-function genes, which control petal, stamen, and carpel development, are functionally dependent on three highly similar MADS-box genes, SEP1, SEP2, and SEP3 (Pelaz et al., 2000). Interestingly, only when mutant knockout alleles of the three SEP genes were combined in a triple sep1 sep2 sep3 mutant was loss of petal, stamen, and carpel identity observed, resulting in a flower composed of only sepals. This example shows that redundancy occurs in the MADS-box gene family, which complicates reverse genetic strategies for gene function analysis. The SHP genes provide another example of MADS-box gene redundancy. shp1 and shp2 single mutants do not exhibit any phenotypic effect, whereas in the double mutant, development of the dehiscence zone is disturbed in the fruit, resulting in a failure to release seeds (Liljegren et al., 2000)[1].

It has been proposed that there are at least 2 lineages (type I and type II) of MADS-box genes in plants, animals, and fungi. Most of the well-studied plant genes are type II genes and have three more domains than type I genes from the N to the C terminus of the protein:intervening (I) domain (~30 codons), keratin-lik e coiled-coil (K) domain (~70 codons), and Cterminal (C) domain (variable length). These genes are called the MIKC-type and are specific to plants[2].

The MADS-box is a DNA binding domain of 58 amino acids that binds DNA at consensus recognition sequences known as CArG boxes [CC(A/T)6GG] (Hayes et al., 1988; Riechmann et al., 1996b). The interaction with DNA has been studied in detail for the human and yeast MADS-box proteins thanks to the resolved crystal structures (Pellegrini et al., 1995; Santelli and Richmond, 2000). The I domain is less conserved and contributes to the specification of dimerization. The K domain is characterized by a coiled-coil structure, which facilitates the dimerization of MADS-box proteins (Davies et al., 1996; Fan et al., 1997). The C domain is the least conserved domain; in some cases, it has been shown to contain a transactivation domain or to contribute to the formation of multimeric MADS-box protein complexes (Egea-Cortines et al., 1999; Honma and Goto, 2001)[1].

1.Parenicova L, de Folter S, Kieffer M, Horner DS, Favalli C, Busscher J, Cook HE, Ingram RM, Kater MM, Davies B, Angenent GC, Colombo L.
Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world.
Plant Cell. 2003 Jul;15(7):1538-51.
PMID: 12837945
2.Nam J, dePamphilis CW, Ma H, Nei M.
Antiquity and evolution of the MADS-box gene family controlling flower development in plants.
Mol Biol Evol. 2003 Sep;20(9):1435-47. Epub 2003 May 30.
PMID: 12777513